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The grape antioxidant resveratrol has been a topic of intense research for the past three decades. Resveratrol and other grape ingredients, as well as whole-grape products, have shown considerable promise in health promotion and disease management.
Phytochemically, whole grape represents a natural combination of resveratrol and other phytonutrients, as it contains several catechins, anthocyanins, polyphenols, and flavonols. Thus, the whole grape products or specific combinations of grape constituents provide us with the possibility of synergistic interactions leading to improved efficacy.
Recent research has suggested that whole-grape products may help in maintaining heart health and protect against aging, aging-associated diseases, neurodegeneration, and some cancers. Based on the available recent literature, the grape or whole-grape products seem to be safer choices for better health and disease prevention.
However, for advanced disease conditions, individual grape ingredients (such as resveratrol) or combinations of multiple ingredients together with existing therapies appear to be better approaches.
Further clinical studies are needed to understand the benefits of grapes and their products in the prevention and management of specific diseases.
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Although resveratrol has been identified in over 70 plant species, grape and grape products are obvious preferable dietary sources to avail the health-promoting effects of resveratrol.
Phytochemical analysis of grape powder suggests that it contains several catechins, anthocyanins, polyphenols, and flavonols and therefore may represent a natural combination of resveratrol with other valuable phytonutrients. In this review, we discuss studies suggesting the health-promoting effects of whole grape and grape powder, which contain resveratrol as well as numerous other ingredients.